Table 1 IMPROVE-IT HRM outcomes [29, 30, 62, 64, 65, 70,71,72,73]

Feasibility

1. Participant recruitment rates

2. Participant retention rate

3. Trial resource utilization, costs

4. Recommendation acceptance rates by primary team

5. Recommendation acceptance rates by patient

6. Recommendation adherence rates by patient

7. CPT consultation volume capacity

8. Potential to intervene entirely virtually (online)

Clinical

1. Medication management outcomes

a) # inappropriate medications, # drug therapy problems improved, # high-risk medication problems improved, all measured by APEQ

b) # medications per patient end study versus baseline

2. Adverse drug events including adverse drug withdrawal event

3. Medication errors, including preventability

4. Patient problems with medications questionnaire (includes general adherence)

5. Patient knowledge of medications

6. Coordination and continuity of care

7. Patient quality of life (EQ-5D-5L and medication-related QOL)

8. Satisfaction with care (patients and providers)

9. Health resource utilization, including clinical events of death, ED visits, hospitalizations, physician visits, other providers including diagnostics utilization, medication costs