Table 3 Study objectives and outcomes
Objective | Measurement | Timepoint |
|---|---|---|
Aim 1: Feasibility | Recruitment and retention | Throughout study |
Self-reported compliance on Cr supplement calendar | Throughout intervention | |
Serum creatine (Cr) levels | Baseline, 4 weeks, and 8 weeks | |
Aim 2: Brain creatine concentration | Magnetic resonance spectroscopy measurement of brain total creatine (Cr) | Baseline and 8 weeks |
Aim 3: Cognition | NIH-Toolbox® Cognitive Battery | Baseline and 8 weeks |
Aim 4: Peripheral mitochondrial function | OROBOROS Oxygraph-2 K measurement of platelet and lymphocyte respiration, ATP production, and ROS production | Baseline and 8 weeks |
Aim 4: Brain mitochondrial function | Magnetic resonance spectroscopy measurement of brain N-acetylaspartate (NAA) and glutathione (GSH) | Baseline and 8 weeks |
Aim 5: Muscle strength and morphology | Handgrip strength, leg extensor strength, and quadriceps ultrasound | Baseline and 8 weeks |