Table 1 Full inclusion criteria

Consent

Willing and able to give informed consent for participation in the trial, reconfirmed verbally at each clinic visit

Agree to have study visits video and/or audio recorded

Agree to inform the Investigators within 48 h of any medical conditions and procedures being undertaken

Willing for the investigators to communicate directly with their medical team to determine medical suitability for study participation (oncologist, GP, palliative care physician, etc.)

Agree to refrain from starting any new psychiatric medication and/or psychotherapy during the study period

Agree to have transportation other than driving themselves to where they are staying on the days of medication dosing

Able and willing to be contacted via telephone for all necessary telephone contacts

Agree to use an effective form of contraception if of child-bearing potential for the duration of medication dosing

Must provide a contact/support person if they are unreachable by study staff or in the event of severe distress or suicidality

Agree to not use any medications on the prohibited medications list during the study

Agree not to take any herbal supplement for the duration of medication dosing (except with prior approval of the research team)

Demographics

At least 25 years old

Proficient in speaking and reading English

Clinical characteristics

Diagnosis with an incurable stage IV incurable solid organ malignancy

Prognosis of at least 6 months life expectancy from the time of screening

Moderate distress (4 or greater) as measured by the distress thermometer